Primary Outcomes For Resuscitation Research

Primary Outcomes for Resuscitation Science Studies
A Consensus Statement From the American Heart Association


  • The AHA guidelines for the treatment of cardiac arrest are based on high-quality clinical trials, which depend on the selection of a meaningful primary outcome.
  • This consensus statement is intended for researchers, clinicians, reviewers, and regulators in the selection of the most appropriate primary outcome for clinical trials of cardiac arrest therapies.
  • This paper focuses on (1) when after cardiac arrest the measurement time point should occur; (2) what cardiovascular, neurological, and other physiology should be assessed; and (3) the costs associated with various end points.

    Read the full article in Circulation
    2011, published online before print October 3, 2011, 10.1161/CIR.0b013e3182340239

Supporting Materials

  • Commentary – "Selecting the Right Primary Outcome Measures for Cardiac Arrest Research: We Can Pay Now, or We Can Pay Later" by Bentley J. Bobrow, MD, FACEP (Emergency Medicine)
  • Commentary – "Survival vs. Functional Outcome: What Does Really Matter and How Do We Measure It in Resuscitation Science?" by Salvador Cruz-Flores, MD, MPH, FAHA (Neurology)
  • Top Ten Things To Know



Related Statements and Guidelines





Posted by Stacy AHA Science on Oct 3, 2011 3:09 PM America/Chicago