STROKE WEBINAR #26
STROKE Webinar Series
brought to you by STROKE
A Journal of the American Heart Association/American Stroke Association
NOW AVAILABLE ONLINE
Join Stroke, a journal of the American Heart Association ǀ American Stroke Association, for a new webinar:
Stroke Recovery: Timing, Training, and Biological Determinants
Steven R. Zeiler, MD, PhD, Presenter
Webinar Registration Homepage
Motor recovery after stroke can occur either via reductions in impairment or through compensation. Studies in humans and nonhuman animal models show that most recovery from impairment occurs in the first 1 to 3 months after stroke as a result of both spontaneous reorganization and increased responsiveness to enriched environments and training. Improvement from impairment is attributable to a short lived, sensitive period of postischemic plasticity defined by unique genetic, molecular, physiological, and structural events. In contrast, compensation can occur at any time after stroke. Data suggests that there are three important variables that determine the degree of motor recovery from impairment all else being equal: (i) the timing, intensity, and approach to training with respect to stroke onset; (ii) the unique postischemic plasticity milieu; and (iii) the extent of cortical reorganization. I will present data regarding both the biology of the brain’s poststroke sensitive period and the difficult question of what kind of interventions best exploit this period. Future work will need to further characterize the interaction between types of training and postischemic plasticity, and find ways to augment and prolong the sensitive period using pharmacological agents or noninvasive brain stimulation.
In this lecture, Dr. Zeiler will discuss:
1. The inadequacy of current clinical stroke rehabilitation.
2. The correct timing of clinical stroke rehabilitation.
3. Data as to why there is a sensitive period for stroke recovery.