Science News from the American Heart Association
MicroRNA-21 Regulates Vascular Smooth Muscle Cell Function via Targeting Tropomyosin 1 in Arteriosclerosis Obliterans of Lower Extremities
Wang M, Li W, Chang G-Q, Ye C-S, Ou J-S, Li X-X, Liu Y, Cheang T-Y, Huang X-L, Wang S-M. MicroRNA-21 Regulates Vascular Smooth Muscle Cell Function via Targeting Tropomyosin 1 in Arteriosclerosis Obliterans of Lower Extremities. Arterioscler Thromb Vasc Biol. 2011;31:2044-2053, doi:10.1161/ATVBAHA.111.229559
By targeting tropomyosin1, MicroRNA-21 (miR-21) regulates arterial smooth muscle cell function by targeting tropomyosin 1, playing an important role in obliterans (ASO). Although more research is warranted, these findings might provide a new therapeutic target for human ASO.
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