Science News from the American Heart Association
MicroRNA-21 Regulates Vascular Smooth Muscle Cell Function via Targeting Tropomyosin 1 in Arteriosclerosis Obliterans of Lower Extremities
Wang M, Li W, Chang G-Q, Ye C-S, Ou J-S, Li X-X, Liu Y, Cheang T-Y, Huang X-L, Wang S-M. MicroRNA-21 Regulates Vascular Smooth Muscle Cell Function via Targeting Tropomyosin 1 in Arteriosclerosis Obliterans of Lower Extremities. Arterioscler Thromb Vasc Biol. 2011;31:2044-2053, doi:10.1161/ATVBAHA.111.229559
By targeting tropomyosin1, MicroRNA-21 (miR-21) regulates arterial smooth muscle cell function by targeting tropomyosin 1, playing an important role in obliterans (ASO). Although more research is warranted, these findings might provide a new therapeutic target for human ASO.
Substantial Reduction in Single Sympathetic Nerve Firing After Renal Denervation in Patients With Resistant Hypertension
Hering D, Lambert EA, Marusic P, Walton AS, Krum H, Lambert GW, Esler MD, Schlaich MP. Substantial Reduction in Single Sympathetic Nerve Firing After Renal Denervation in Patients with Resistant Hypertension. Hypertension. 2013;61:457-464, doi:10.1161/HYPERTENSIONAHA.111.00194
In patients with resistant hypertension, renal denervation has been shown to reduce blood pressure and muscle sympathetic nerve activity. Renal denervation was shown to influence the rapid reduction in firing properties of single sympathetic vasoconstrictor fibers.
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