Primary Outcomes for Resuscitation Science Studies
A Consensus Statement From the American Heart Association
The AHA guidelines for the treatment of cardiac arrest are based on high-quality clinical trials, which depend on the selection of a meaningful primary outcome.
This consensus statement is intended for researchers, clinicians, reviewers, and regulators in the selection of the most appropriate primary outcome for clinical trials of cardiac arrest therapies.
This paper focuses on (1) when after cardiac arrest the measurement time point should occur; (2) what cardiovascular, neurological, and other physiology should be assessed; and (3) the costs associated with various end points.