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Temperature Management After Cardiac Arrest

  • For more than a decade, mild induced hypothermia (32°C–34°C) has been standard of care for patients remaining comatose after resuscitation from out-of-hospital cardiac arrest with an initial shockable rhythm, and this has been extrapolated to survivors of cardiac arrest with initially nonshockable rhythms and to patients with in-hospital cardiac arrest.
  • Two randomized trials published in 2002 reported a survival and neurologic benefit with mild-induced hypothermia. One recent randomized trial reported similar outcomes in patients treated with targeted temperature management at either 33°C or 36°C.
  • In response to these new data, the International Liaison Committee on Resuscitation (ILCOR) Advanced Life Support (ALS) Task Force performed a systematic review to evaluate 3 key questions: Should mild induced hypothermia (or some form of targeted temperature management) be used in comatose post-cardiac arrest patients?
    • If used, what is the ideal timing of the intervention?
    • If used, what is the ideal duration of the intervention?
  • The Task Force used GRADE (Grading of Recommendations Assessment, Development and Evaluation) methodology to assess and summarize the evidence, and to provide a consensus on science statement and treatment recommendations.
  • The Task Force recommends targeted temperature management for adults with out-of-hospital cardiac arrest with an initial shockable rhythm at a constant temperature between 32°C and 36°C for at least 24 hours.
  • Similar suggestions are made for out-of-hospital cardiac arrest with a nonshockable rhythm and in-hospital cardiac arrest.
  • The Task Force recommends against prehospital cooling with rapid infusion of large volumes of cold intravenous fluid.
  • Additional and specific recommendations are provided in the document.

Read the full article in Circulation

Posted by Kelly Kozakowski on Oct 2, 2015 12:32 PM CDT
Council on Hypertension 2015 Scientific Sessions
Washington, D.C.
September 16 - 19, 2015

Thursday, September 17, 2015
More Advances in Hypertension Research:
Hypertension & the Gut, and Women & Cardiovascular Disease

Welcome to SCIENCE NEWS coverage of HTN 2015.

Posted by Kelly Kozakowski on Sep 17, 2015 4:19 PM CDT

Infective Endocarditis in Childhood: 2015 Update

  • This scientific statement is an update of the 2002 AHA statement “Unique Features of Infective Endocarditis in Childhood.”
  • The increased survival of children with congenital heart disease and the related complex surgeries using prosthetic materials have changed the epidemiology and microbiology of infective endocarditis.
  • Outpatient management now includes home intravenous therapy for select patients.
    Read the full article in Circulation
Posted by Kelly Kozakowski on Sep 15, 2015 5:01 PM CDT

Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications

  • Infective endocarditis (IE), a complex and potentially lethal disease, has undergone major changes in both the host patients and the pathogens involved.
  • This scientific statement updates the 2005 AHA scientific statement “Infective Endocarditis: Diagnosis, Antimicrobial Therapy, and Management of Complications.”
  • A multidisciplinary team is needed to manage adult patients with IE.
    Read the full article in Circulation
Posted by Kelly Kozakowski on Sep 15, 2015 5:01 PM CDT

Current Science on Consumer Use of Mobile Health for Cardiovascular Disease Prevention

  • Mortality from cardiovascular disease has declined in recent decades, but unhealthy behaviors such as unhealthy body weight, sedentary behaviors, and tobacco use remain prevalent in the U.S. population. The American Heart Association 2020 Strategic Impact Goals target health behaviors and health indicators.
  • Mobile technologies are a pervasive component of the modern American environment and mobile devices permit collection of data in real time – enabling researchers to assess multiple behaviors in various contexts and inform the development of interventions to prompt behavior change.
  • While many mobile health interventions do not currently have the evidence base to support their inclusion in clinical recommendations, they hold great promise for lifestyle interventions to promote better patient health.
    Read the full article in Circulation
Posted by Kelly Kozakowski on Aug 13, 2015 3:48 PM CDT

Major Depressive Disorder and Bipolar Disorder Predispose Youth to Accelerated Atherosclerosis and Early Cardiovascular Disease

  • Major Depressive Disorder (MDD) and Bipolar Disorder (BD) affects about 10% of adolescents in the US.
  • The association between depression and CVD among adults is well known.
  • MDD and BD among youth satisfy the criteria for, and should be included in the list of, moderate risk conditions for cardiovascular disease along with chronic inflammatory disease, human immunodeficiency virus, and nephrotic syndrome.

    Read the full article in Circulation
Posted by Stacy AHA Science on Aug 10, 2015 3:25 PM CDT

Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence

  • After reaching a peak in the 1960s, mortality rates from coronary artery disease (CAD) have declined steadily in the United States. While there has also been improvements in CAD mortality in people with type 2 diabetes mellitus, they are at incrementally higher cardiovascular risk than nondiabetics.
  • This scientific statement provides a focused update of recent studies on CVD risk factor control and prevention, and screening for renal and subclinical coronary artery disease in people with diabetes.
  • Several key research questions remain to make greater strides in lowering clinical cardiovascular disease in this high-risk patient population.

    Read the full article in Circulation
Posted by Kelly Kozakowski on Aug 5, 2015 1:12 PM CDT

Social Determinants of Risk and Outcomes for Cardiovascular Disease

  • The prevalence of CVD is expected to rise in the US by 10% between 2010 and 2030, and it is argued that this is not explained solely by an aging population.
  • This statement summarizes the current state of knowledge about social factors as they relate to health.
  • Future directions are discussed as it relates to research that may attenuate these factors.

    Read the full article in Circulation
Posted by Kelly Kozakowski on Aug 4, 2015 2:28 PM CDT

Transformative Impact of Proteomics on Cardiovascular Health and Disease

  • The American Heart Association (AHA) summarizes advances in proteomics over the past 20 years that have catalyzed the capacity to address the experimental, translational, and clinical implications as applied to cardiovascular health and disease.
  • The statement extends beyond the typical literature review and offers guidance on the use of next-generation proteomics for future scientific discovery in the basic research laboratory and clinical settings.
  • Key successes that have energized the field are delineated in this statement; opportunities for proteomics to drive basic science research, facilitate clinical translation, and established diagnostic and therapeutic healthcare algorithms are discussed.
  • Challenges that remain to be solved before proteomic technologies can be readily translated from scientific discoveries to meaningful advances in cardiovascular care are also addressed.

    Read the full article in Circulation
Posted by Kelly Kozakowski on Jul 20, 2015 4:30 PM CDT


2015 AHA/ASA Focused Update of the 2013 Guidelines for the Early Management of Patients With Acute Ischemic Stroke Regarding Endovascular Treatment

  • This update to the 2013 AIS Guideline provides an update to the management is ischemic stroke for endovascular treatment.
  • The AHA/ASA recommends, in addition to IV rtPA, endovascular treatment with stent retrievers in persons with a large cerebral artery occlusion (M1).
  • Key recommendations are made regarding the use of IV rtPA, endovascular treatment with stent retrievers, imaging and systems of care.
Read the full article in Stroke
Posted by Kelly Kozakowski on Jul 20, 2015 1:34 PM CDT
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